A Crystalline Serum Muco-Protein with High Choline-Esterase Activity
نویسندگان
چکیده
منابع مشابه
The Choline-esterase Activity of the Blood Serum in Disease.
The investigations of Dale and his coworkers (1, 2) on the chemical transmission of parasympathetic nerve stimulation and of Walker (3, 4) on the use of physostigmine and prostigmin in myasthenia gravis have stimulated interest in the choline-esterase activity of serum. Lucas, Hall, and Ettinger (5) studied the serum esterase activity of 200 subjects and obtained results that were in essential ...
متن کاملCcl. the Relative Choline-esterase Activities of Serum
FOLLOWING the discovery by Stedman et al. [1932] that the destruction of acetylcholine by blood serum was brought about by a specific enzyme, which they termed choline-esterase, Stedman et al. [1933] examined the blood sera from a number of species for the presence of this enzyme and compared the cholineesterase activities of these sera with their activities towards two other types of esters, n...
متن کاملLxxii. Properties of Choline Esterase in Human Serum
THE importance of the physiologically active substance acetylcholine makes it highly desirable that the properties of the enzyme which specifically hydrolyses choline esters be established. Summaries of the past work on this enzyme have recently appeared [Ammon, 1935; Gaddum, 1935; Oppenheimer, 1935]. It is remarkable that although choline esterase has been studied in relation to its partial pu...
متن کاملMultiple forms of sheep serum A-esterase activity associated with the high-density lipoprotein.
Five lipoproteins of sheep serum expressing A-esterase activity, but with differing activities towards four organophosphate substrates, were separated by a combination of gel filtration and ion-exchange chromatography. Each had an Mr of approx. 360,000 and contained a major peptide of Mr 28,000-30,000 that appeared to be present as several isoforms on urea/agarose isoelectric focusing. In every...
متن کاملSerum Albumin Binding and Esterase Activity: Mechanistic Interactions with Organophosphates.
The albumin molecule, in contrast to many other plasma proteins, is not covered with a carbohydrate moiety and can bind and transport various molecules of endogenous and exogenous origin. The enzymatic activity of albumin, the existence of which many scientists perceive skeptically, is much less studied. In toxicology, understanding the mechanistic interactions of organophosphates with albumin ...
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ژورنال
عنوان ژورنال: Nature
سال: 1944
ISSN: 0028-0836,1476-4687
DOI: 10.1038/154737a0